The Pilot Program at the Washington National Primate Research Center (WaNPRC) provides the specialized research facilities, expertise and limited support to investigators.
In most cases, pilot projects are focused on unique or emerging research opportunities, requiring preliminary studies to generate scientific data that will lead to future expanded grant applications for independent funding.
The Institute of Translational Health Sciences (ITHS) and the Center annually co-sponsor the Career Development and Ignition Awards. The awards support preclinical translational research in the areas of non-human primate models of human disease, drug delivery, transport, metabolism, and manufacturing.
The Institute for Translational Health Sciences (ITHS) and the Washington National Primate Research Center (WaNPRC) are pleased to sponsor the Ignition Award, focusing on the use of nonhuman primate models of human disease. The purpose of this Ignition Award is to explore innovative areas of nonhuman primate (NHP) research and generate preliminary data to serve as a basis for submission of new research grant applications (e.g. R01-type grant to NIH or other funding agency) and/or subsequent clinical studies. There will be up to three awards: one with the primary focus on translational applications; and up to two pilot awards, focusing on the development or enhancement of the use of nonhuman primates as animal models.
All faculty members or those with equivalent titles are eligible to apply.
The WaNPRC intends to allocate up to three separate awards of up to $65,000 each. The award will be administered by the Primate Center and must be used for Primate Center study costs, including animal costs, per diem, procedures, supplies and salaries. This award is not intended to support outgoing subcontracts.
This program is designed to support innovative studies utilizing resources within the WaNPRC. Nonhuman primates are the preeminent animal model of the human condition. This award program will facilitate use of NHP models and services of the WaNPRC and resources within the ITHS to provide information applicable to subsequent grant and/or clinical studies. This program will provide an opportunity to advance research programs developing and expanding the use of nonhuman primates in research of human diseases, also, by operating jointly with the ITHS, advance the translational process of development and use of therapeutics, diagnostics or device development.
Examples of translational projects include, but are not limited to:
- The development of clinical tests/diagnostics/therapeutics that have the potential to
- speed translational research (i.e., new outcome measures)
- improve clinical treatments (i.e., new therapeutics or new indications for approved drugs)
- Advance neuroscience applications, surgical techniques
- Reproductive / developmental studies that can have direct clinical applications
Application Process Details
Step 1 – Submit the application to WaNPRC
Due Friday, February 20, 2015
No UW GC1 is necessary.
No applications time stamped after 2/20/15, 11:00 PM will be considered
Step 2 – Review of Applications
Reviews are performed utilizing the standards described above
Applicants will be notified of their status by March 30, 2015. Applicants will receive a copy of the reviewers’ notes of their application.
NOTE: The PIs receiving awards are responsible for securing approval from the UW Institutional Animal Care and Use Committee before a new project can begin.
Investigators are offered assistance with their applications and budgets by WaNPRC staff. Budget review before submission of the application is advised, to ensure that the correct pricing is used. Requests for assistance can be sent to via email to: PrimateITHS@wanprc.org
Step 3 – 2015 Award recipients
Budget period is anticipated to begin May 1, 2015 and must be spent by April 30, 2016. There will not be any option for a no-cost extension or carry-forward.
Unsuccessful applicants may resubmit their applications for the next round up to a total of two (2) times. The Review Committee may deny the opportunity to resubmit an application if the reviewers determine the application does not meet the intent of the program.
Review Criteria and Committee Details:
The combined Research Review Committee (RRC) for the Ignition Award applications will consist of members of the WaNPRC, and the ITHS Drug and Device Advisory Committee (DDAC). Members of the committee are selected to provide interdisciplinary insight into the proposed research. The committee is composed of core and affiliate scientists. If potential conflict of interest exists, ad hoc members will be appointed. If the committee does not feel the membership includes the necessary scientific expertise to provide an adequate review, an ad hoc reviewer will be added for that application.
As needed, the WaNPRC will also invite representation from the Center for Commercialization for guidance on innovation represented by the technology.
Applications will be critiqued and scored by the RRC. It is anticipated that the projects with the lowest score/highest priority will be funded. Based on funding levels, it is anticipated that two or three projects will be funded during this 2015 review cycle.
Reviews are performed according to the following standards:
- Applicability to the WaNPRC and ITHS missions
- Scientific merit
- Proposed activities conducted on site at the WaNPRC
- Potential impact on human health
- Probability of future grant funding and/or clinical studies
All faculty members (or those with equivalent titles) are eligible to apply, except those who have received an ITHS/Primate Center Ignition Award within the previous three years.
Applicants are encouraged to contact the WaNPRC [Ann Schmidt (Research Liaison)] at: PrimateITHS@wanprc.org to discuss the scientific components of their projects, WaNPRC resources available and general costs of the services to be provided. Complete budgets are required for the Full Applications. It is advised to develop the budgets in collaboration with the WaNPRC. The budgets for the NHP studies will be administered by the WaNPRC. All financial activity will be overseen by the WaNPRC Finance and Administration Office.
- It is the PI’s responsibility to clearly demonstrate how the proposed research has the potential to positively impact the quality or the conduct of clinical and translational research.
- The PI should clearly describe how the proposed evaluation methodology provides an innovative approach to conducting the proposed research.
- Up to $65,000 per selected applicant will be directly applied to the costs at the WaNPRC.
- No additional funds will be provided for indirect costs. The budgets associated with these awards are an allocation from the base grant and will be administered by the WaNPRC.
- It is expected that these applications and awards will not include any outgoing subcontracts.
Ignition Awards are an investment in translational research to improve human health. Meetings with ITHS representatives to assess the effective utilization of ITHS resources and required progress and results reporting are important aspects that aid in evaluating the success of this funding mechanism.
ITHS and WaNPRC each have specific requirements for reporting.
The ITHS requires the following reports and presentations (if applicable):
- Pre-award meeting with the DDAC to establish other ITHS resources that would benefit your program.
- Semi-annual progress report.
- Annual report and presentation to DDAC.
The WaNPRC requires an annual report; this will be included with the Annual Progress Report to the sponsor. This will be due in Jan-Feb 2016.
Quarterly in-person meetings with an ITHS representative may be requested to track the progress of funded activities.
The WaNPRC and the ITHS reserves the right to publicly disclose information about its granting activities. ITHS communications to the public may include lists of funded applications, the names of principal investigators and applicant institutions and departments, titles of proposed activities and reports about progress and outcomes. Please note that records produced at the University of Washington are subject to the Washington State Public Records Act, Chapter 42.56 RCW.