AIDS-Related Diseases
Providing expertise and resources to better understand, prevent and treat HIV and AIDS.
Nonhuman Primate Systems Biology
Using systems biology and computational modeling to understand infection and immunology.
Global Programs
Focusing on conservation biology, field study training and emerging infectious diseases.
Neuroscience
Using the primate model to answer questions about the nervous system, vision and more.
Reproductive & Developmental Sciences
Exploring reproductive biology, stem cell research and cognitive development.
Evolutionary Emergence of Infectious Diseases
Understanding how interspecies interaction leads to the emergence of disease.
Venture/Pilot Program
Providing specialized facilities, expertise and support to investigators with approved projects.

Division of Nonhuman Primate Systems Biology

The Center is unique in its ability to simultaneously apply and integrate genomic, proteomic, bioinformatic, and immunologic analyses to the characterization of nonhuman primate models of virus infection. The Center has established the Division of Nonhuman Primate Systems Biology to integrate complementary technologies to provide previously unavailable characterization of nonhuman primate response to infectious agents and vaccines.

The four Cores of the division—Genomics, Proteomics, Protective Immunity, and Animal Models—provide the resources needed to analyze nonhuman primates at multiple points along the flow of biological information; from the whole animal to DNA to RNA to protein to biological function. By integrating these diverse types of data, we have the opportunity to better understand the dynamics of the host response to infection and the molecular mechanisms underlying the progression to virus-mediated disease, immunopathology, or the development of protective immunity. We also have the opportunity to better understand how gene expression changes (in response to infection) translate into changes in protein abundance and function, and how these changes correlate with clinical outcome.

This multilayered and integrated approach also allows us to evaluate the biological significance of specific gene expression changes. Moreover, by working with an animal model, we can assess how changes in gene expression and protein abundance affect immune cell function, and how the innate immune response develops and its link to adaptive immunity. This integrated approach can translate into molecular signatures that predict protective immunity or pathology, biomarkers for diagnostic or prognostic assays, and a rational base for improvements to antiviral therapies or vaccine strategies.

For more information on primate genomics, please visit macaque.org.

Core Staff Scientists

Name
WaNPRC Division
Position
UW Department(s)
Shiu-Lok Hu

AIDS-Related Diseases

Nonhuman Primate
Systems Biology
Core Staff ScientistDepartment of Pharmaceutics
Michael G. Katze
Nonhuman Primate
Systems Biology

AIDS-Related Diseases
Core Staff ScientistDepartment of Microbiology