The Center is unique in its ability to simultaneously apply genomic, proteomic, metabolomic, and bioinformatic analyses to the characterization of nonhuman primate biomedical models. The Division of Nonhuman Primate Systems Biology integrates these complementary technologies to provide previously unavailable characterization of the nonhuman primate response to infectious agents and vaccines.
The two Cores of the Division—the High-throughput Molecular Profiling Core and the Statistical Analysis and Computational Modeling Core—provide the resources needed to analyze nonhuman primates at multiple points along the flow of biological information; from the whole animal to single cells, and from DNA to RNA to protein to biological function. By integrating these diverse types of data, we can learn how gene expression changes correlate with changes in protein abundance, modification, and function. We also have the opportunity to better understand the dynamics of the host response to infection and the molecular mechanisms underlying the progression to virus-mediated disease, immunopathology, or the development of protective immunity.
Moreover, by working with an animal model, we can assess how changes in gene expression or protein abundance or modification affect immune cell function, and how the innate immune response develops and its link to adaptive immunity. This integrated approach can translate into molecular signatures that predict protective immunity or pathology, biomarkers for diagnostic or prognostic assays, and a rational base for improvements to antiviral therapies and vaccines.
The Division is also active in developing nonhuman primate genomic resources, including the Nonhuman Primate Reference Transcriptome Resource, which contains reference transcriptome information for 15 nonhuman primate species. For more information on this resource, please visit nhprtr.org.
Transcriptional profiling (RNA-seq and microarray) and bioinformatic and computational analyses are also available on a fee-for-service basis through Division-operated Sound Genomics.
Core Staff Scientists
|Name||WaNPRC Division||Position||UW Department(s)|
|Shiu-Lok Hu||AIDS-Related Diseases|
|Core Staff Scientist||Department of Pharmaceutics|
|Michael G. Katze||Nonhuman Primate|
|Core Staff Scientist||Department of Microbiology|