The Infectious Disease & Translational Medicine Division is comprised of three Resource Cores: Virology & Immunology Core (V&IC), the High Throughput Molecular Profiling Core, and the Computer Data Analysis Core. Through these cores, the division supports the following programs: Core Research Program, Affiliate Research Program and Training Program.
The division includes both core and affiliate investigators with a broad spectrum of active research programs. The Core Research Program currently includes core investigators maintaining active research programs in the following areas:
- Vaccine research
- Evaluation of anti-HIV drugs and microbicides
- Animal models
- Molecular Biology
The Affiliate Research Program includes many research affiliates and collaborators outside of the Center who routinely utilize the Center’s scientific, technical, laboratory and animal resources. The Affiliate Research Program encompasses all aspects of AIDS-related research.
All members of the Core Research Program participate in the training of personnel conducting AIDS-related research. Besides training of students, fellows, research technologists and other professionals, members of division also host national and international visiting scholars, conduct seminars and organize research meetings to promote and utilize the intellectual and scientific resources at the Center.
The Center is unique in its ability to simultaneously apply genomic, proteomic, metabolomic, and bioinformatic analyses to the characterization of nonhuman primate biomedical models. The Division of Nonhuman Primate Systems Biology integrates these complementary technologies to provide previously unavailable characterization of the nonhuman primate response to infectious agents and vaccines.
The High Throughput Molecular Profiling Core and the Computer Data Analysis Cores—provide the resources needed to analyze nonhuman primates at multiple points along the flow of biological information; from the whole animal to single cells, and from DNA to RNA to protein to biological function. By integrating these diverse types of data, we can learn how gene expression changes correlate with changes in protein abundance, modification, and function. We also have the opportunity to better understand the dynamics of the host response to infection and the molecular mechanisms underlying the progression to virus-mediated disease, immunopathology, or the development of protective immunity.
Moreover, by working with an animal model, we can assess how changes in gene expression or protein abundance or modification affect immune cell function, and how the innate immune response develops and its link to adaptive immunity. This integrated approach can translate into molecular signatures that predict protective immunity or pathology, biomarkers for diagnostic or prognostic assays, and a rational base for improvements to antiviral therapies and vaccines.
Transcriptional profiling (RNA-seq and microarray) and bioinformatic and computational analyses are also available on a fee-for-service basis through Division-operated Seattle Genomics.
Core Staff Scientists
|Name||WaNPRC Division||Position||UW Department(s)|
|Deborah Heydenburg Fuller||Infectious Diseases and Translational Medicine, Virology and Immunology Core||Chief - Core Staff Scientist||Department of Microbiology|
|Kristina Adams Waldorf||Infectious Diseases and Translational Medicine; Reproductive and Fetal Health||Core Staff Scientist||Department of Obstetrics & Gynecology|
|Lakshmi Rajagopal||Infectious Diseases and Translational Medicine; Reproductive and Fetal Health||IDTM Affiliate Researcher||Department of Global Health|
|Jacob D. Estes||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|Andrew McGuire||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|Carl Fredrik Barrenäs||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|Dan H. Barouch||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|David Watkins||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher||Department of Medicine: General Internal Medicine|
|Jan Komorowski||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|Jennifer Manuzak||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|Louis Picker||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher|
|Kim Woodrow||Infectious Diseases and Translational Medicine||IDTM Affiliate Researcher||Department of Bioengineering|
|Michael Gale, Jr.||Infectious Diseases and Translational Medicine; Systems Biology, Seattle Genomics||Core Staff Scientist||Department of Immunology
Department of Microbiology & Global Health
|Dorothy Patton||Infectious Diseases and Translational Medicine; Reproductive and Fetal Health||IDTM Affiliate Researcher||Department of Obstetrics & Gynecology|
|Shiu-Lok Hu||Infectious Disease & Translational Medicine; AIDS-related Diseases, Virology Core||Core Staff Scientist||Department of Pharmaceutics|
|Sean Murphy||Infectious Disease & Translational Medicine||Core Staff Scientist||Departments of Lab Medicine
Department of Microbiology
|Melanie Shears||Infectious Disease & Translational Medicine||IDTM Affiliate Researcher||Department of Laboratory Medicine and Pathology
|Rodney JY Ho||Infectious Disease & Translational Medicine||IDTM Affiliate Researcher||Department of Pharmaceutics|